NEWS
SigmaStat v1.0 Launches with ARAI, Combining Powerful Statistics with Intelligent Guidance
By: Grafiti LLC
PALO ALTO, Calif. - Aug. 17, 2026 - PRLog -- Grafiti Launches SigmaStat V1 Statistical Software with On-Device AI
PALO ALTO, Calif. — Grafiti LLC has launched SigmaStat V1, a statistical analysis platform for researchers, engineers, and students, the company announced today. The software includes guided statistical workflows, regression and predictive modeling tools, and 2D/3D graphing, along with a new on-device AI assistant called ARAI.
Unlike cloud-based AI tools, ARAI runs locally on the user's device, so research data does not leave the machine. Grafiti said ARAI is designed to help users choose and understand the applicability of statistical tests, while the underlying statistical computations continue to run on established statistical methods rather than AI.
"Our vision at Grafiti has always been to serve the scientific community," said Shirish Tangirala, Chief Operating Officer of Grafiti. "With SigmaStat V1, we've begun incorporating AI into our products for the first time — on-device, for privacy, and focused on guidance rather than replacing the statistics itself."
SigmaStat V1 is available now for Windows 10 and 11. macOS support for Intel and Apple Silicon devices is planned.
Grafiti LLC, based in Palo Alto, California, builds statistical software for scientific researchers, engineers, analysts, and academic institutions.
For all enquires please email sales@4amsoftware.com.au
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SigmaPlot version 16 released
We are pleased to inform all Sigma Plot users that Sigma Plot version 16 has been released. We are updating our websites with the most recent information on this version.
Customers who are under maintenance will receive this new version as part of their existing maintenance contracts.
Customers who are not under maintenance can upgrade by paying the upgrade fee. We will be rolling out this delivery to our customers under maintenance starting within the next 2 to 6 weeks or earlier.
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Meet us at the trade desk – Molecular Modelling Conference 2023 - 7th to 10th Dec 2023
We are the Bronze Sponsor’s for this event
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Meet us at the exhibit hall – 28-30 September 2022, 2002 Parkville Vic
Intuitive Solutions for effective Molecule design
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SigmaPlot version 15 released
We are pleased to inform all Sigma Plot users that Sigma Plot version 15 has been released. We are updating our websites with the most recent information on this version. Customers who are under maintenance will receive this new version as part of their existing maintenance contracts. Customers who are not under maintenance can upgrade by paying the upgrade fee.
We will be rolling out this delivery to our customers under maintenance starting within the next 2 to 6 weeks or earlier.
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4am Software Pty Ltd. appointed as distributor of Cresset computational solutions for drug discovery
Brisbane, Australia and Cambridge, UK – 29 September 2020 – 4am Software Pty Ltd., announces its appointment as distributor of Cresset computational solutions for small molecule discovery in Australia and New Zealand. The agreement will provide researchers in these territories with improved access to Cresset’s range of desktop and web-based solutions, developed to optimize and accelerate drug discovery processes.
The technology uses Cresset’s proprietary descriptors of molecular electrostatics and shape to understand key interactions underpinning biological activity. The applications represented include:
- Blaze™ ligand-based virtual screening tool
- Flare™ streamlined structure-based design platform with access to an extended range of scientific capabilities
- Forge™ ligand-based workbench providing an informative approach to molecule design and SAR analysis
- Spark™ scaffold hopping and R-group exploration software
- PickR™ monomer selection tool for high quality libraries and better intellectual property
- Torx™ web-based platform to accelerate Design-Make-Test-Analyze workflow (in collaboration with Elixir Software)
“Cresset is renowned for providing intuitive ligand-based and structure-based software which enables computational and medicinal chemists to design better molecules”, said Clifford Snell, Director at 4am Software. “By representing Cresset in Australia and New Zealand we can ensure pharmaceutical and biotechnology companies, and academics, have access to some of the best solutions on the market to progress their drug discovery projects.”
“We are excited to grow our network of distributors in the Asia-Pacific region, and work with 4am Software to support drug discovery research in Australia and New Zealand. Our 3D design workbenches, Forge and Flare, integrate cutting-edge science to provide a user-friendly approach to ligand- and structure-based drug design, respectively. A recent release of Flare increases the speed and accessibility of Free Energy Perturbation (FEP) calculations, making it easier to predict the activity of new molecules.”, said David Bardsley, Commercial Director at Cresset. “We were delighted to see that the power of our bioisostere replacement tool, Spark, was recently validated by the results of an external evaluation (Baumgartner and Evans, Side chain virtual screening of matched molecular pairs: a PDB-wide and ChemBL-wide analysis, J. Comput. Aided Mol. Des. 2020). Additionally, Torx, our web-based platform for small molecule discovery, enables teams to work together, even at this time when individuals may be working fragmented shifts or from home offices. We look forward to working with 4am Software so that computational and medicinal chemists in Australia and New Zealand can enhance their toolbox with this comprehensive array of software solutions.”
Generate highly innovative ideas for your project to escape IP and toxicity traps with Spark
Contacts
Cresset: Sue Peffer, Head of Marketing, news@cresset-group.com
4am Software Pty: Clifford Snell, sales@4amsoftware.com.au
About 4am Software Pty
4am Software represents some of the world’s leading organizations to provide state-of-the-art products, solutions and services in the Asia Pacific region, including Australia and NZ. Supporting and supplying organizations, universities, defence, industry, corporates, pharma research and CRO organization, that are seeking solutions within tight schedules and budgets while being mindful of the environment. This rich experience has provided the knowledge of driving ROI and profits for its customers. www.4amsoftware.com.au
About Cresset
Chemists in the world’s leading research organizations use Cresset software and discovery services to discover, design and optimize the best small molecules. Our patented software and expert scientists offer unrivalled insight into protein-ligand systems, enabling chemists to accelerate their research in industry sectors including: pharmaceuticals, agrochemicals, fine chemicals and flavors and fragrances. www.cresset-group.com